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Page 1
Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Abdellatif M, Trummer-Herbst V, Heberle AM, Humnig A, Pendl T, Durand S, Cerrato G, Hofer SJ, Islam M, Voglhuber J, Ramos Pittol JM, Kepp O, Hoefler G, Schmidt A, Rainer PP, Scherr D, von Lewinski D, Bisping E, McMullen JR, Diwan A, Eisenberg T, Madeo F, Thedieck K, Kroemer G, Sedej S. Abdellatif M, et al. Among authors: heberle am. Circulation. 2022 Jun 21;145(25):1853-1866. doi: 10.1161/CIRCULATIONAHA.122.059863. Epub 2022 May 26. Circulation. 2022. PMID: 35616058 Free PMC article.
Finding new edges: systems approaches to MTOR signaling.
Heberle AM, Rehbein U, Rodríguez Peiris M, Thedieck K. Heberle AM, et al. Biochem Soc Trans. 2021 Feb 26;49(1):41-54. doi: 10.1042/BST20190730. Biochem Soc Trans. 2021. PMID: 33544134 Free PMC article. Review.
mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases.
Cadena Sandoval M, Heberle AM, Rehbein U, Barile C, Ramos Pittol JM, Thedieck K. Cadena Sandoval M, et al. Among authors: heberle am. Front Aging. 2021 Oct 13;2:761333. doi: 10.3389/fragi.2021.761333. eCollection 2021. Front Aging. 2021. PMID: 35822040 Free PMC article. Review.
Molecular mechanisms of mTOR regulation by stress.
Heberle AM, Prentzell MT, van Eunen K, Bakker BM, Grellscheid SN, Thedieck K. Heberle AM, et al. Mol Cell Oncol. 2014 Dec 3;2(2):e970489. doi: 10.4161/23723548.2014.970489. eCollection 2015 Apr-Jun. Mol Cell Oncol. 2014. PMID: 27308421 Free PMC article. Review.
The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back.
Rehbein U, Prentzell MT, Cadena Sandoval M, Heberle AM, Henske EP, Opitz CA, Thedieck K. Rehbein U, et al. Among authors: heberle am. Front Cell Dev Biol. 2021 Oct 29;9:751892. doi: 10.3389/fcell.2021.751892. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34778262 Free PMC article. Review.
Cardiac PI3K p110α attenuation delays aging and extends lifespan.
Abdellatif M, Eisenberg T, Heberle AM, Thedieck K, Kroemer G, Sedej S. Abdellatif M, et al. Among authors: heberle am. Cell Stress. 2022 Aug 8;6(8):72-75. doi: 10.15698/cst2022.08.270. eCollection 2022 Aug. Cell Stress. 2022. PMID: 36447531 Free PMC article.
Tomatidine, a novel antiviral compound towards dengue virus.
Diosa-Toro M, Troost B, van de Pol D, Heberle AM, Urcuqui-Inchima S, Thedieck K, Smit JM. Diosa-Toro M, et al. Among authors: heberle am. Antiviral Res. 2019 Jan;161:90-99. doi: 10.1016/j.antiviral.2018.11.011. Epub 2018 Nov 22. Antiviral Res. 2019. PMID: 30468746 Free article.
The PI3K and MAPK/p38 pathways control stress granule assembly in a hierarchical manner.
Heberle AM, Razquin Navas P, Langelaar-Makkinje M, Kasack K, Sadik A, Faessler E, Hahn U, Marx-Stoelting P, Opitz CA, Sers C, Heiland I, Schäuble S, Thedieck K. Heberle AM, et al. Life Sci Alliance. 2019 Mar 28;2(2):e201800257. doi: 10.26508/lsa.201800257. Print 2019 Apr. Life Sci Alliance. 2019. PMID: 30923191 Free PMC article.
PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy.
Ruf S, Heberle AM, Langelaar-Makkinje M, Gelino S, Wilkinson D, Gerbeth C, Schwarz JJ, Holzwarth B, Warscheid B, Meisinger C, van Vugt MA, Baumeister R, Hansen M, Thedieck K. Ruf S, et al. Among authors: heberle am. Autophagy. 2017 Mar 4;13(3):486-505. doi: 10.1080/15548627.2016.1263781. Epub 2017 Jan 19. Autophagy. 2017. PMID: 28102733 Free PMC article.